VDR is a gene which encodes for a protein that acts as a receptor vitamin D that regulates bone formation and calcium absorption. A variant of the gene called the rs2228570 (FokI polymorphism), is associated with lower bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern and the temporal occupancy of the VDRE between the two components. It is also affected by chromosomal location and binding preferences for specific hormones. Studies of microarrays in human cells reveal that more than 100 genes are enriched with a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for data and documents pertinent to legal transactions, business or proceedings with restrictions on viewing, downloading or printing. It is accessed via central computers and an extranet, which is a restricted-access Internet connection that allows users to access the internet at specific times.
VDRs are primarily used by investment banks and companies involved in mergers and acquisitions. They need to be able to share information in a transparent manner with potential investors or buyers. Due diligence processes can also require a large amount of information. Life science companies also use VDRs to keep everything from clinical trial results to HIPAA documentation.